مقاله Distribution of HLA-B*27 Alleles in Pa-tients with Ankylosing Spondylitis in Iran

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 مقاله Distribution of HLA-B*27 Alleles in Pa-tients with Ankylosing Spondylitis in Iran دارای ۱۰ صفحه می باشد و دارای تنظیمات در microsoft word می باشد و آماده پرینت یا چاپ است

فایل ورد مقاله Distribution of HLA-B*27 Alleles in Pa-tients with Ankylosing Spondylitis in Iran  کاملا فرمت بندی و تنظیم شده در استاندارد دانشگاه  و مراکز دولتی می باشد.

توجه : در صورت  مشاهده  بهم ریختگی احتمالی در متون زیر ،دلیل ان کپی کردن این مطالب از داخل فایل ورد می باشد و در فایل اصلی مقاله Distribution of HLA-B*27 Alleles in Pa-tients with Ankylosing Spondylitis in Iran،به هیچ وجه بهم ریختگی وجود ندارد

بخشی از متن مقاله Distribution of HLA-B*27 Alleles in Pa-tients with Ankylosing Spondylitis in Iran :

سال انتشار : ۲۰۰۹

تعداد صفحات :۱۰

Background: HLA-B*27 is strongly associated with ankylosing spondylitis (AS). It represents a family of alleles that differ among ethnic groups. Objective: The aim of this study was to determine the distribution of HLA-B*27 alleles in AS patients and healthy controls in Isfahan (Iran). Methods: Sixty AS patients and 430 healthy blood donors were selected. All subjects were HLA-B*27 positive by flow cytometry. HLAB* 27 subtypes were determined by PCR-SSP. Results: Forty patients (66.7%) and 17 controls (3.95%) were HLA-B*27 positive. Subtypes detected by PCR-SSP were B*2705, B*2702, B*2704 and B*2707. One patient was B*2702/B*2710. No significant difference was found in the distribution of these alleles between AS patients and controls. Conclusion: Although Caucasian subtypes are predominant among Iranians, this population is characterized by a combination of both specific Caucasian and Oriental subtypes. However such results should be interpreted carefully because of the small sample size in our investigation and definitive conclusion awaits more ethnicgroup studies.