مقاله Study of Antimetastatic Effect of Genistein Through Inhibition of Expression of Matrix Metalloproteinase in A-549 Cell Line

مقاله Study of Antimetastatic Effect of Genistein 
Through Inhibition of Expression of Matrix Metalloproteinase in A-549 Cell Line

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مقاله Study of Antimetastatic Effect of Genistein
Through Inhibition of Expression of Matrix Metalloproteinase in A-549 Cell Line دارای 13 صفحه می باشد و دارای تنظیمات در microsoft word می باشد و آماده پرینت یا چاپ است

فایل ورد مقاله Study of Antimetastatic Effect of Genistein
Through Inhibition of Expression of Matrix Metalloproteinase in A-549 Cell Line کاملا فرمت بندی و تنظیم شده در استاندارد دانشگاه و مراکز دولتی می باشد.

توجه : در صورت  مشاهده  بهم ريختگي احتمالي در متون زير ،دليل ان کپي کردن اين مطالب از داخل فایل ورد مي باشد و در فايل اصلي مقاله Study of Antimetastatic Effect of Genistein
Through Inhibition of Expression of Matrix Metalloproteinase in A-549 Cell Line،به هيچ وجه بهم ريختگي وجود ندارد


بخشی از متن مقاله Study of Antimetastatic Effect of Genistein
Through Inhibition of Expression of Matrix Metalloproteinase in A-549 Cell Line :

تعداد صفحات :13

The lung cancer is one of the most dangerous cancers and is also the leading cause of cancer death worldwide, accounting for about 1.3 million deaths annually. However in clinical practice, lung cancer therapies commonly do with chemotherapy, although it is hard because the lung cancer may progress to metastasis stage. The metastasis of lung cancer is highly dependent of expression of matrix metalloproteinase, and correlated with phosphorylation of ERK1/2 and PI3K/Akt pathways. Therefore agents’ down expressed matrix metalloproteinase or suppressed phosphorylation of ERK1/2 and PI3K/Akt pathways could inhibit the metastasis stage. In this study we aimed to investigate the effects of genistein, an isoflavonoid, on A-549 cell line. Lactate dehydrogenase (LDH) release, Microculture tetrazolium test (MTT assay), real-time PCR and zymography were used to evaluate the effects of genistein on cell cytotoxicity, cell proliferation, expression of mRNA and protein of MMP-2 in lung cancer A549 cell line. The results indicated that genistein, in a dose-dependent manner, without applying any cytotoxic effect, inhibited cell proliferation and downregulated MMP-2 mRNA and protein expression in A549 cell line. In addition, results of inhibition of ERK1/2 and PI3K/Akt pathways phosphorylation by ELISA indicated that genistein inhibited phosphorylation rate of both pathways. Therefore it seems that genistein can decrease recurrence and decreased the migration and invasion of human non-small cell lung cancer cells (A549 cell line) by an efficient antimetastatic effect. This issue should be further examined for the clinical treatment.

با سلام،محصول دانلودی مقاله Study of Antimetastatic Effect of Genistein
Through Inhibition of Expression of Matrix Metalloproteinase in A-549 Cell Line آماده ارائه به شما پژوهنده عزیز میباشد.با کلیک روی دکمه ادامه مطلب به صفحه توضیحات کامل مقاله Study of Antimetastatic Effect of Genistein
Through Inhibition of Expression of Matrix Metalloproteinase in A-549 Cell Line هدایت میشوید
مقاله Study of Antimetastatic Effect of Genistein
Through Inhibition of Expression of Matrix Metalloproteinase in A-549 Cell Line

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Through Inhibition of Expression of Matrix Metalloproteinase in A-549 Cell Line با تنظیمات کامل و دقیق آماده مطالعه و بررسی شما می باشد شما با دانلود فایل مقاله Study of Antimetastatic Effect of Genistein
Through Inhibition of Expression of Matrix Metalloproteinase in A-549 Cell Line دیگر نیاز به ویرایش اساسی در داخل فایل را ندارید برای مشاهده بخشی از متن فایل بر روی دکمه “توضیحات بیشتر ” در پایین این متن کلیک کنید.
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Through Inhibition of Expression of Matrix Metalloproteinase in A-549 Cell Line وارد صفحه فروش فایل دانلودی مقاله Study of Antimetastatic Effect of Genistein
Through Inhibition of Expression of Matrix Metalloproteinase in A-549 Cell Line شده اید.
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مقاله Study of Antimetastatic Effect of Genistein
Through Inhibition of Expression of Matrix Metalloproteinase in A-549 Cell Line